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Product Name EGFL7 Chinese Name 类表皮生长因子域7抗体 Alias EGF like domain 7; EGF like domain containing protein 7; EGF like domain multiple 7; EGFL 7; Epidermal growth factor like domain protein 7; MEGF 7; MEGF7; MGC111117; Multiple EGF like domain protein 7; Multiple epidermal growth factor like domain protein 7; NEU1 protein; NOTCH4 like protein; RP11 251M1.2; Vascular endothelial statin; VE statin; ZNEU 1; ZNEU1; EGFL7_HUMAN; EGFL7_MOUSE. literatures Specific References (1) | SL1755R has been referenced in 1 publications.[IF=2.24] Huang, Chunhai, et al. "VE-statin/Egfl7 expression in malignant glioma and its relevant molecular network." International Journal of Clinical Experimental Pathololgy 7.3 (2014): 1022-1031. IHC-P ; Human.Research Area Tumour Cell biology immunology Growth factors and hormones transcriptional regulatory factor Kinases and Phosphatases endothelial cells Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse EGFL7: 31-130/275 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail EGFL7 (EGF-like domain-containing protein 7) regulates vascular tubulogenesis in vivo. During sprouting angiogenesis, groups of endothelial cells (ECs) migrate together in units called sprouts. EGFL7 regulates the proper spatial organization of ECs within each sprout and influences their collective movement. It inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro.
Function:
Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro.
Subcellular Location:
Secreted (By similarity).
Tissue Specificity:
Expressed specifically by endothelial cells of the highly vascularized organs heart, lung and kidney.
Similarity:
Contains 2 EGF-like domains.
Contains 1 EMI domain.
SWISS:
Q9QXT5
Gene ID:
353156
Database links:Entrez Gene: 51162 Human
Entrez Gene: 353156 Mouse
Omim: 608582 Human
SwissProt: Q9UHF1 Human
Unigene: 91481 Human
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