Product Name	Anti-CRR9/PE-Cy5.5
Chinese Name	PE-Cy5.5标记的顺氯氨铂耐药相关蛋白9抗体
Alias	Cisplatin resistance related protein 9; Cisplatin resistance related protein CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1 like protein; Cleft lip and palate transmembrane protein 1-like protein; CLP1L_HUMAN; CLPTM1 like; CLPTM1 like protein; CLPTM1-like protein; CLPTM1L; CRR9; CRR9p.
Research Area	Tumour  Cell biology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	62kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CLPTM1L/CRR9
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Clefts of the oral-facial region usually occur in early fetal development and can affect the lip, the soft palate and the hard palate. Cleft lip (with or without cleft palate) is a genetically complex birth defect that occurs in approximately one in every 750-1,000 live births. This is one of the most common birth defects and is multifactorial, with both genetic and environmental causes. Cleft lip- and palate-associated transmembrane protein 1 (CLPTM1) belongs to a family of cleft lip and palate transmembrane proteins. This family also contains cisplatin resistance-related protein (CRR9), which is involved in CDDP-induced apoptosis. CLPTM1L (cleft lip and palate transmembrane protein 1-like protein), also known as CRR9p (cisplatin resistance-related protein 9) is a 538 amino acid multi-pass membrane protein that belongs to the CLPTM1 family and, when overexpressed, enhances cisplatin-mediated apoptosis. CLPTM1L exists as two alternatively spliced isoforms encoded by a gene that maps to human chromosome 5p15.33. Function: Enhances cisplatin-mediated apoptosis, when overexpressed. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Similarity: Belongs to the CLPTM1 family Database links: Entrez Gene: 81037 Human Omim: 612585 Human SwissProt: Q96KA5 Human Unigene: 444673 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 顺氯氨铂属于细胞周期非特异性药物，具有细胞毒性，可抑制癌细胞的DNA复制过程，并损伤其The cell membrane上结构，有较强的广谱抗癌作用。临床用于卵巢癌、前列腺癌、睾丸癌、肺癌、鼻咽癌、食道癌、恶性淋巴瘤、乳腺癌、头颈部鳞癌、甲状腺癌及成骨肉瘤等多种实体Tumour均能显示疗效。

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