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Product Name Anti-VCAM1/HRP Chinese Name 辣根过氧化物酶标记的vascular endothelial cell粘附分子抗体 Alias VCAM1; CD 106; CD106; CD106 Antigen; DKFZp779G2333; INCAM 100; MGC99561; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; INCAM-100; V-CAM 1; VCAM1_HUMAN. Research Area Tumour Cardiovascular Cell biology Cell adhesion molecule endothelial cells Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rabbit, Sheep, (predicted: Rat, Pig, ) Applications WB=1:500-2000 ELISA=1:100-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 81kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human VCAM-1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.
Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit:
Binds to ECMV-D capsid proteins and acts as a receptor for this virus.
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity:
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
Similarity:
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Database links:Entrez Gene: 7412 Human
Entrez Gene: 22329 Mouse
GenBank: NP_001069.1 Human
GenBank: NP_001186763.1 Human
Omim: 192225 Human
SwissProt: P19320 Human
SwissProt: P29533 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞粘附蛋白(Call Adhesion Protein)
CD106是一种膜相关蛋白,分布于血管内皮及其周围的lymphocyte、单核细胞、嗜酸性粒细胞和中性粒细胞。Anti-VCAM-1主要用于各种组织中血管内皮的检测。
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