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Product Name Anti-MMP10/HRP Chinese Name 辣根过氧化物酶标记的基质金属蛋白酶-10抗体 Alias Matrix metalloproteinase 10; Matrix metalloproteinase-10; matrix metalloproteinase 10; MMP-10; Mmp10; MMP10_HUMAN; SL 2; SL2; STMY 2; Stromelysin 2; Stromelysin II; Stromelysin-2; Stromelysin2; StromelysinII; Transin 2; Transin-2; Transin2; stromelysin 2; SL-2; STMY2; MMP 10; AV377895, MMP10. Research Area Tumour Cardiovascular Cell biology Extracellular matrix Ubiquitin Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 43kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MMP10 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Function:
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
Subcellular Location:
Secreted, extracellular space, extracellular matrix (Probable).
Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.
Database links:Entrez Gene: 4319 Human
Entrez Gene: 17384 Mouse
Omim: 185260 Human
SwissProt: P09238 Human
SwissProt: O55123 Mouse
Unigene: 2258 Human
Unigene: 14126 Mouse
Unigene: 9946 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Synthesis and Degradation(Synthesis and Degradation)
MMP10主要用于一些恶性Tumour,如乳腺癌、胃肠道癌、卵巢癌等与转移浸润的研究。
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