Product Name	LAMP1 Rabbit pAb, PE conjugated
Chinese Name	PE标记的溶酶体相关膜蛋白1（CD107）抗体
Alias	FCG3A_CD107 antigen like family member A; CD107 antigen-like family member A; CD107a; CD107a antigen; LAMP 1; LAMP-1; LAMP1_HUMAN; LAMPA; LGP120; lgpA; Lysosomal membrane glycoprotein 120KD; Lysosomal Associated Membrane Protein 1; Lysosome associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1;
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human
Applications	Flow-Cyt=2ug/Test Excitation spectrum: 496nm,564nm Emission spectrum: 578nm not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	27kDa
Cellular localization	Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	Recombinant human LAMP1 protein: 29-382/417
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. Database links: Entrez Gene : 3916 Human Entrez Gene : 16783 Mouse Entrez Gene : 25328 Rat Omim : 153330 Human SwissProt : P11279 Human SwissProt : P11438 Mouse SwissProt : P14562 Rat Unigene : 494419 Human Unigene : 16716 Mouse Unigene : 475822 Mouse Unigene : 40177 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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