TEL: 0086-571-56623320    EMAIL: SALES@SUNLONGBIOTECH.COM

Your Position: Home > Product Center > Antibody > Marker Primary AB > Mouse Anti-Ki-67/APC Conjugated antibody

View History

Mouse Anti-Ki-67/APC Conjugated antibody

Mouse Anti-Ki-67/APC Conjugated antibody

next

  • Cat NO.:SLM33070M-APC
  • Product Spec:100ul
  • Clonality:Monoclonal
  • Price:$496
  • Total:
  • Quantity:
  • Manual

Goods Brief:

© 2005-2021 Elisa kit,Antibody-Sunlong Biotech Co.,Ltd Copyright, All Rights Reserved.
Product Name Anti-Ki-67/APC
Chinese Name APC标记的Ki67蛋白单克隆抗体
Alias Antigen identified by monoclonal antibody Ki 67; Antigen KI67; KIA; Ki-67; Ki67; MKI67; Proliferation related Ki 67 antigen; Antigen KI-67; KI67_HUMAN.  
Organism Species Mouse
Clonality Monoclonal
Clone NO 6B9
React Species Human, Mouse, Rat, 
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 358kDa
Form Lyophilized or Liquid
Concentration 2mg/1ml
immunogen KLH conjugated synthetic peptide derived from human Ki-67
Lsotype IgG
Purification affinity purified by Protein G
Storage Buffer Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

Function:
Thought to be required for maintaining cell proliferation.

Subcellular Location:
Nucleus. Chromosome. Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.

Similarity:
Contains 1 FHA domain.

Database links:
Entrez Gene: 4288 Human

Entrez Gene: 17345 Mouse

Entrez Gene: 246042 Rat

Omim: 176741 Human

SwissProt: P46013 Human

SwissProt: Q91VE6 Mouse

SwissProt: Q5RJM0 Rat

Unigene: 689823 Human

Unigene: 80976 Human

Unigene: 4078 Mouse

Unigene: 233802 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞增殖Maker(Proliferation Marker)
Ki67与PCNA一样,为细胞增殖的一种标记,在Apoptosis中S、G2 、M期均有表达,G0期缺如。 Ki-67增殖指数高低与许多Tumour的分化程度、浸润、转移以及预后密切相关,因此被广泛作为各种恶性Tumour的必检项目之一。