Cytochalasin A

 

Cytochalasin A, A metabolite of Drechslera dematoidea, can inhibit the growth and glucose transport of yeast strains. Cytorelaxin A is an oxidative analogue of cell protease B. Inhibit HIV-1 protease.

Alias: Dehydrophomin

Molecular formula: C29H35NO5, molecular weight: 477.59

Physical properties and indexes:

Appearance: …………………… White crystalline powder

Melting point: …………………… 190 ~ 191 ° C

Solubility: ………………… Soluble in DMSO(20mg/ml), ethanol (20mg/ml), insoluble in water.

Burning residue: ……………… < 0.1%

Purity: …………………… > 98%

Biological activity

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such  diverse processes as cell movement, growth, phagocytosis, degranulation,  and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3  μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 ofDictyostelium,  activating STATc.

Recommended solution preparation (for reference only)

Cytochalasin A is A solid crystalline powder, soluble in ethanol or DMSO, but difficult to dissolve in water. In order to enhance its solubility in water, cytochalasin A can be dissolved in DMF first, and then dissolved in water, the solubility of approximately 0.05mg/ml in 1:20 DMF/PBS.

Usage and Description:

Scientific research reagent

Storage conditions:

 

15 ~ 20 ° C

 

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