Product Name	FAT4
Chinese Name	FAT4单克隆抗体
Alias	CDHF14; FAT4_HUMAN; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FATJ; hFat4; Nbla00548; Protocadherin Fat 4.
literatures	Specific References  (1)     |     SLM-51726M has been referenced in 1 publications. [IF=3.738] Yang, Yuying. et al. FAT4 activation inhibits epithelial-mesenchymal transition (EMT) by promoting autophagy in H2228/Cer cells. MED ONCOL. 2023 Jan;40(1):1-12  WB ;  Human.   PubMed:36576661
Research Area	Tumour  Signal transduction  Cell adhesion molecule  Cell differentiation
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	H10M4
React Species	Human,
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	538kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human FAT4 between 4500-4786 amino acids
Lsotype	IgG1,k
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014] Function: May function in the regulation of planar cell polarity. Cadherins are cell-cell interaction molecules. Subcellular Location: Membrane. In the kidney, localizes to primary cilia. Tissue Specificity: Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. Similarity: Contains 34 cadherin domains. Contains 6 EGF-like domains. Contains 2 laminin G-like domains. SWISS: Q6V0I7 Gene ID: 79633 Database links: Entrez Gene: 79633 Human SwissProt: Q6V0I7 Human Unigene: 563205 Human
Product Picture	Sample: Lane 1: FAT4 Recombinant protein Primary: Anti-FAT4 (SLM-51726M) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 538 kD Observed band size: 45 kD

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