Product Name	TMPO
Chinese Name	胸腺生成素LAP2单克隆抗体
Alias	LAP2; LAP2A_HUMAN; Isoforms beta/gamma; Lamina associated polypeptide 2 alpha; Lamina associated polypeptide 2; Thymopoietin; Thymopoietin isoform alpha; TP alpha; TP; LAP2-alpha; LAP2 alpha.
Research Area	Chromatin and nuclear signals  Epigenetics  Ubiquitin
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	A2D12
React Species	Human,
Applications	WB=1:500-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	83kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human TMPO
Lsotype	IgG1,κ
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019] Function: Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent- and salt-resistant nucleoskeletal structure. Subunit: Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages. Subcellular Location: Nuclear Tissue Specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver. Post-translational modifications: Phosphorylated in a mitose-specific manner. DISEASE: Cardiomyopathy, dilated 1T (CMD1T) [MIM:613740]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the LEM family. Contains 1 LEM domain. Contains 1 LEM-like domain. SWISS: Q96RT1 Gene ID: 7112 Database links: Entrez Gene: 7112 Human SwissProt: P42166 Human
Product Picture	Sample: Lane 1: Hela cell lysates Lane 2: SW480 cell lysates Primary: Anti-TMPO (SLM-51721M) at 1/500~1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 83 kD Observed band size:180 kD

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