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Product Name MIR16 Chinese Name 膜蛋白相互作用蛋白GDE1 (MIR16)单克隆抗体 Alias GDE1; GDE1_HUMAN; EC 3.1.4.44; Glycerophosphodiester phosphodiesterase 1; Glycerophosphoinositol glycerophosphodiesterase GDE1; Membrane interacting protein of RGS16; Membrane-interacting protein of RGS16; RGS16 interacting membrane protein; RGS16-interacting membrane protein; Lysophospholipase D GDE1. Research Area Cell biology Neurobiology Signal transduction glycoprotein Immunogen Species Mouse Clonality Monoclonal Clone NO. E10F6 React Species Human, Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 38kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen Recombinant humans GDE1. Lsotype IgG1,κ Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail GDE1 is a 331 amino acid multi-pass membrane protein that localizes to both the membrane and the cytoplasm and contains one GDPD domain. Expressed in a wide variety of tissues, GDE1 uses magnesium as a cofactor to catalyze the conversion of 1-(sn-glycero-3-phospho)-1D-myo-inositol to myo-inositol and sn-glycerol 3-phosphate, an event that is modulated by G protein signaling pathways and provides a link between phosphoinositide metabolism and G protein signal transduction. The gene encoding GDE1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Function:
MIR6 has glycerophosphoinositol phosphodiesterase activity.
Subunit:
Interacts with RGS16. Interacts with PRAF2.
Subcellular Location:
Cytoplasmic. Membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
N-glycosylated
Similarity:
Belongs to the glycerophosphoryl diester phosphodiesterase family.
Contains 1 GDPD domain.
SWISS:
Q9NZC3
Gene ID:
51573
Database links:Entrez Gene: 51573 Human
Omim: 605943 Human
SwissProt: Q9NZC3 Human
Unigene: 512607 Human
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