Product Name	DUSP2
Chinese Name	双特异性磷酸酶2抗体
Alias	Dual specificity phosphatase 2; Dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC 1; DUSP 2; PAC 1; PAC1; Serine/threonine specific protein phosphatase; DUS2_HUMAN.
Research Area	Cell biology  Signal transduction  Apoptosis  Cyclin  transcriptional regulatory factor  Kinases and Phosphatases  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DUSP2: 201-314/314
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	DUSP2 is a dual-specific thr/tyr phosphatase that is a physiologically relevant MAP kinase phosphatase. The gene is located on 2q11.2-q11 and contains 4 exons that span approximately 2.3kb. Under specific stress conditions, p53 regulates transcription of PAC1 through a new p53-binding site, and that PAC1 is necessary and sufficient for p53-mediated apoptosis. Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Subcellular Location: Nucleus. Tissue Specificity: Expressed in hematopoietic tissues. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 rhodanese domain. Contains 1 tyrosine-protein phosphatase domain. SWISS: Q05923 Gene ID: 1844 Database links: Entrez Gene: 1844 Human Entrez Gene: 13537 Mouse Omim: 603068 Human SwissProt: Q05923 Human SwissProt: Q05922 Mouse Unigene: 1183 Human Unigene: 4729 Mouse

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