Product Name	AEN
Chinese Name	Apoptosis增强核酸酶抗体
Alias	AEN_HUMAN; apoptosis enhancing nuclease; Apoptosis-enhancing nuclease; Interferon stimulated exonuclease gene 20kDa like 1; Interferon stimulated exonuclease gene 20kDa like 1, isoform CRA_a; Interferon-stimulated 20 kDa exonuclease-like 1; ISG20L1; pp12744.
Research Area	Cell biology  Chromatin and nuclear signals  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Apoptosis enhancing nuclease: 1-100/325
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. Function: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. Subcellular Location: Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction. Similarity: Contains 1 exonuclease domain. SWISS: Q8WTP8 Gene ID: 64782 Database links: Entrez Gene: 64782 Human SwissProt: Q8WTP8 Human

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