Product Name	RHBDD3
Chinese Name	垂体瘤Apoptosis抗体
Alias	C22orf3; HS984G1A; Pituitary tumor apoptosis; PTAG; RHBD3_HUMAN; RHBDD3; Rhomboid domain containing 3; Rhomboid domain-containing protein 3.
Research Area	Cell biology  Neurobiology  Apoptosis  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RHBDD3: 151-250/386
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PTAG is a novel 386 amino acid multi-pass membrane protein that contains one UBA domain and augments drug-induced apoptosis. Cells lacking PTAG have a reduced apoptotic response, thereby causing a predisposition to cell malignancy and resistance to chemotherapeutic interventions, and PTAG plays a role in colorectal tumorigenesis as the majority of primary colorectal tumors lack the PTAG gene. Encoded by a gene located on human chromosome 22, PTAG is often co-expressed with EWS (ewing sarcoma breakpoint region 1), a gene located directly downstream of PTAG. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Similarity: Contains 1 UBA domain SWISS: Q9Y3P4 Gene ID: 25807 Database links: Entrez Gene: 25807 Human Entrez Gene: 279766 Mouse Entrez Gene: 289753 Rat SwissProt: Q9Y3P4 Human SwissProt: Q8BP97 Mouse SwissProt: Q642B3 Rat Unigene: 106730 Human Unigene: 260866 Mouse Unigene: 9606 Rat RHBDD3分子是一个全新的TLR信号途径的负向调控蛋白分子,是一个能够显著抑制自身免疫性疾病发生的效应分子,RHBDD3控制机体避免发生过度的免疫应答、防止自身免疫性疾病的发生具有重要意义。
Product Picture	Sample: Testis (Mouse) Lysate at 40 ug Heart (Mouse) Lysate at 40 ug Liver (Mouse) Lysate at 40 ug Placenta (Mouse) Lysate at 40 ug Spleen (Mouse) Lysate at 40 ug Cerebrum (Mouse) Lysate at 40 ug Skeletal muscle (Mouse) Lysate at 40 ug A431(Human) Cell Lysate at 30 ug HL60(Human) Cell Lysate at 30 ug A549(Human) Cell Lysate at 30 ug Molt-4(Human) Cell Lysate at 30 ug Primary: Anti- RHBDD3 (SL7566R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33’51 kD Observed band size: 51 kD

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