Product Name	PGC1 beta
Chinese Name	过氧化物酶体增殖物激活受体γ辅激活子1β抗体
Alias	PERC; peroxisome proliferative activated receptor, gamma, coactivator 1,; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1(beta); PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC1; PPAR gamma coactivator-1beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; PPARGC1; Ppargc1b; PRGC2_HUMAN.
literatures	Specific References  (4)     |     SL7534R has been referenced in 4 publications. [IF=5.988] Lei Zhao. et al. Polysaccharides From Pogostemon cablin (Blanco) Benth.: Characterization and Antioxidant Activities. FRONT PHARMACOL. 2022; 13: 933669  WB ;  Mouse.   PubMed:35784681 [IF=4.12] Zhou, Jing-Jing, et al. "Down-regulating peroxisome proliferator-activated receptor-gamma coactivator-1beta alleviates the proinflammatory effect of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting extracellular signal-regulated kinase, p38 and nuclear factor-kappaB activation." Arthritis Research & Therapy 16.5 (2014): 472.  IHC-P ;  Human.   PubMed:25367151 [IF=4.061] Wang Dan. et al. The Effect of Aerobic Exercise on the Oxidative Capacity of Skeletal Muscle Mitochondria in Mice with Impaired Glucose Tolerance. J DIABETES RES. 2022;2022:3780156  WB ;  Mouse.   PubMed:35712028 [IF=3.553] Man Luo. et al. miR136 regulates proliferation and differentiation of small tail han sheep preadipocytes. ADIPOCYTE. 2023;12(1):Article: 2173966  WB ;  Sheep,Human.   PubMed:36722834
Research Area	Cardiovascular  Cell biology  Signal transduction  Diabetes  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	113kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PGC1 beta: 901-1023/1023
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Tissue specificity: Ubiquitous with higher expression in heart, brain and skeletal muscle. Function: Plays a role of stimulator of transcription factors andnuclear receptors activities. Activates transcritional activity ofestrogen receptor alpha, nuclear respiratory factor 1 (NRF1) andglucocorticoid receptor in the presence of glucocorticoids. Mayplay a role in constitutive non-adrenergic-mediated mitochondrialbiogenesis as suggested by increased basal oxygen consumption andmitochondrial number when overexpressed. May be involved in fatoxidation and non-oxidative glucose metabolism and in theregulation of energy expenditure. Subunit: Interacts with hepatocyte nuclear factor 4-alpha/HNF4A,Sterol regulatory binding transcription factor 1/SREBF1,PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cellfactor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRGand alpha/ESRRA. Interacts with PRDM16 (By similarity). Interactswith estrogen receptor alpha/ESR1. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous with higher expression in heart,brain and skeletal muscle. Similarity: Contains 1 RRM (RNA recognition motif) domain. SWISS: Q86YN6 Gene ID: 133522 Database links:   UniProtKB/Swiss-Prot: Q86YN6.2 Entrez Gene: 133522 Human Entrez Gene: 170826 Mouse Entrez Gene: 291567 Rat Omim: 608886 Human SwissProt: Q86YN6 Human SwissProt: Q8VHJ7 Mouse SwissProt: Q811R2 Rat Unigene: 483816 Human

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