Product Name	Islet 1
Chinese Name	胰岛素基因增强Binding protein1抗体
Alias	Insulin gene enhancer protein ISL 1; Insulin gene enhancer protein ISL-1; Insulin related protein; Isl 1; ISL LIM homeobox 1; ISL1; ISL1 transcription factor LIM homeodomain; ISL1 transcription factor, LIM/homeodomain (islet 1); ISL1 transcription factor, LIM/homeodomain; ISL1_HUMAN; Islet-1; Islet1.
Research Area	Cardiovascular  Cell biology  Developmental biology  Neurobiology  Signal transduction  Stem cells  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	39kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Islet 1: 201-300/349
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008] Function: Binds to one of the cis-acting domain of the insulin gene enhancer. Subcellular Location: Nucleus. Tissue Specificity: Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. SWISS: P61371 Gene ID: 3670 Database links: Entrez Gene: 396383 Chicken Entrez Gene: 3670 Human Entrez Gene: 16392 Mouse Entrez Gene: 64444 Rat Omim: 600366 Human SwissProt: P50211 Chicken SwissProt: P61371 Human
Product Picture	Sample: Hela(Human) Cell Lysate at 30 ug Primary: Anti- Islet 1 (SL7532R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD

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