Product Name	Thrombospondin 2
Chinese Name	血小板反应蛋白2/凝血酶敏感蛋白2抗体
Alias	THBS2; Thrombospondin-2; Thrombospondin2; TSP2; TSP2_HUMAN.
literatures	Specific References  (3)     |     SL7524R has been referenced in 3 publications. [IF=4.638] Li Jianxiong. et al. Whole-exome mutational landscape and molecular marker study in mucinous and clear cell ovarian cancer cell lines 3AO and ES2. BMC CANCER. 2023 Dec;23(1):1-13  WB,IF ;  Human.   PubMed:37024829 [IF=2.22] Ken-Go Hayashi. et al. Differential expression of pro- and anti-angiogenic factors in the endometrium between repeat breeder and normally fertile cows. ANIM REPROD SCI. 2023 Jul;254:107265  IHC ;  Bovine.   PubMed:37270879 [IF=1.33] Chen, Junying, et al. "MiR-1246 promotes SiHa cervical cancer cell proliferation, invasion, and migration through suppression of its target gene thrombospondin 2." Archives of Gynecology and Obstetrics (2014): 1-8.  WB ;  Human.   PubMed:24806621
Research Area	Tumour  Cardiovascular  Cell biology  cell factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	128kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Thrombospondin 2: 201-300/1172
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. Subunit: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Tissue Specificity: High expression in invertebral disk tissue. DISEASE: Genetic variations in THBS2 may be a cause of susceptibility to intervertebral disk disease (IDD) [MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain. Similarity: Belongs to the thrombospondin family. Contains 2 EGF-like domains. Contains 1 laminin G-like domain. Contains 1 TSP C-terminal (TSPC) domain. Contains 3 TSP type-1 domains. Contains 8 TSP type-3 repeats. Contains 1 VWFC domain. SWISS: P35442 Gene ID: 7058 Database links: Entrez Gene: 7058 Human Entrez Gene: 21826 Mouse Entrez Gene: 292406 Rat Omim: 188061 Human SwissProt: P35440 Chicken SwissProt: Q95116 Cow SwissProt: P35442 Human SwissProt: Q03350 Mouse Unigene: 797 Chicken Unigene: 5522 Cow Unigene: 371147 Human Unigene: 26688 Mouse
Product Picture	Sample: MG63(Human) Cell Lysate at 40 ug Primary: Anti-Thrombospondin 2 (SL7524R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 128 kD Observed band size: 128 kD Sample: HUVEC(Human) Cell Lysate at 40 ug Primary: Anti-Thrombospondin 2 (SL7524R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 128 kD Observed band size: 128 kD

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