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Product Name PLXNC1/CD232 Chinese Name 细胞表面蛋白CD232抗体 Alias CD232; Plexin-C1; PLXC1_HUMAN; Plxnc1; Virus-encoded semaphorin protein receptor. literatures Specific References (1) | SL7492R has been referenced in 1 publications.[IF=6.684] Zhizhan Ni. et al. PLXNC1: A Novel Potential Immune-Related Target for Stomach Adenocarcinoma. Front Cell Dev Biol. 2021; 9: 662707 IHC ; Human.Research Area Cell biology Neurobiology The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 172kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PLXNC1/CD232: 681-780/1568 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Function:
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8.
Subcellular Location:
Membrane.
Tissue Specificity:
Detected in heart, brain, lung, spleen and placenta.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the plexin family.
Contains 1 Sema domain.
SWISS:
O60486
Gene ID:
10154
Database links:Entrez Gene: 10154 Human
Entrez Gene: 54712 Mouse
Omim: 604259 Human
SwissProt: O60486 Human
SwissProt: Q9QZC2 Mouse
Unigene: 584845 Human
Unigene: 256712 Mouse
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