Product Name	Sprouty 4
Chinese Name	快速发育生长因子同源蛋白4抗体
Alias	Protein sprouty homolog 4; Sprouty homolog 4; sprouty homolog 4 (Drosophila); SPRY 4; Spry-4; Spry4; SPY4_HUMAN.
literatures	Specific References  (1)     |     SL7421R has been referenced in 1 publications. [IF=31.745] Shan-shan Liu. et al. The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity. 2021 Aug;:  WB ;  Mouse.   PubMed:34407391
Research Area	Cell biology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Sprouty 4: 1-100/299
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008] Function: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Subcellular Location: Cytoplasm. Cell projection > ruffle membrane. Similarity: Belongs to the sprouty family. Contains 1 SPR (sprouty) domain. SWISS: Q9C004 Gene ID: 81848 Database links: Entrez Gene: 81848 Human Entrez Gene: 504593 Cow Entrez Gene: 24066 Mouse Omim: 607984 Human SwissProt: A2VDU1 Cow SwissProt: Q9C004 Human SwissProt: Q9WTP2 Mouse Unigene: 323308 Human Unigene: 42038 Mouse

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