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Product Name HAVCR2/TIM-3 Chinese Name HAVCR2(CD366)抗体 Alias TIM-3; Tim 3; TIM3; TIMD-3; TIMD3; HAVR2_HUMAN; Hepatitis A virus cellular receptor 2; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; CD366; literatures Specific References (3) | SL7363R has been referenced in 3 publications.[IF=3.943] Jie Hou. et al. Increased Tim-3+ monocytes/macrophages are associated with disease severity in patients with IgA nephropathy. Int Immunopharmacol. 2021 Aug;97:107666 IF ; Human.[IF=3.223] Shifa Zhang. et al. Impact of the combination of sintilimab and chemotherapy on the tumor and paratumor PD-L1, IDO, TIM-3, FOXP3+ and CD8 expressions in patients with advanced esophageal squamous cell carcinoma. THORAC CANCER. 2022 Oct;: IHC ; Human.[IF=3.118] Qu S et al. The effects of resiquimod in an ovalbumin-induced allergic rhinitis model.Int Immunopharmacol. 2018 Jun;59:233-242. IF ; Mouse.Research Area immunology Cell Surface Molecule t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 31kDa Detection molecular weight 40 kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TIM 3: 101-200/301 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Function:
Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
Subcellular Location:
Membrane.
Tissue Specificity:
T-helper type 1 lymphocyte (Th1)-specific.
Post-translational modifications:
O-glycosylated with core 1 or possibly core 8 glycans.
Similarity:
Belongs to the immunoglobulin superfamily. TIM family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q8TDQ0
Gene ID:
84868
Database links:Entrez Gene: 84868 Human
Omim: 606652 Human
SwissProt: Q8TDQ0 Human
Unigene: 710500 Human
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