Product Name	CARD10
Chinese Name	BCL10Binding protein和激活核转录因子抗体
Alias	Bcl10 binding protein and activator of NFKB; BIMP1; CAR10_HUMAN; CARD 10; CARD-containing MAGUK 3; CARD-containing MAGUK protein 3; CARD10; Carma 3; CARMA3; Caspase Recruitment Domain family member 10; Caspase recruitment domain-containing protein 10.
Research Area	Cell biology  immunology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Monkey, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	116kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CARD10: 165-248/248
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Membrane-associated guanylate kinase (MAGUK) family members function as molecular scaffolds for the assembly of multiprotein complexes localizing to the plasma membrane. Several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product belong to the MAGUK family, including the caspase recruitment domain (CARD) protein family with the exception of CARD9. The CARD domain consists of 6 or 7 antiparallel alpha helices. CARD family members participate in apoptosis signaling through highly specific protein-protein homophilic interactions. CARD 10 (also designated CARD-containing MAGUK protein 3 or Carma 3) interacts with BCL-10 to activate NFⅹB. CARD10 is expressed in a variety of adult and fetal tissues, including heart, kidney and liver, and in multiple cancer cell lines. Function: Activates NF-kappa-B via BCL10 and IKK. Tissue Specificity: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney. Similarity: Contains 1 CARD domain. SWISS: Q9BWT7 Gene ID: 29775 Database links: Entrez Gene: 29775 Human Entrez Gene: 105844 Mouse Omim: 607209 Human SwissProt: Q9BWT7 Human SwissProt: P58660 Mouse Unigene: 57973 Human Unigene: 17629 Mouse

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