Product Name	G6PDH
Chinese Name	己糖6磷酸脱氢酶抗体
Alias	6 phosphogluconolactonase; 6-phosphogluconolactonase; 6PGL; H6PD; DKFZp686A01246; G6PD H form; G6PDH; G6PE_HUMAN; GDH; H6PD; GDH/6PGL endoplasmic bifunctional protein; Glucose 1 dehydrogenase; Glucose 6 phosphate dehydrogenase salivary; Glucose dehyrogenase; Gpd1; H6pd; Hexose 6 phosphate dehydrogenase; Hexose-6-phosphate dehydrogenase; MGC87643.
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	85kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human G6PDH: 321-420/791
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	H6PD (hexose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein) is a 789 amino acid protein encoded by the human gene H6PD. The N-terminal section of H6PD belongs to the glucose-6-phosphate dehydrogenase family, while the C-terminal section belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily. H6PD is responsible primarily for the oxidation of glucose-6-phosphate and glucose. It also oxidizes other hexose-6-phosphates. H6PD catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor for the reductase activity of 11∫-hydroxysteroid dehydrogenase type 1, which converts hormonally inactive cortisone to active cortisol (in rodents, 11-dehydrocorticosterone to corticosterone). Function: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. Subcellular Location: Endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen. Tissue Specificity: Present in most tissues examined, strongest in liver. DISEASE: Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Similarity: In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family. In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. SWISS: O95336 Gene ID: 9563 Database links: Entrez Gene: 25796 Human Entrez Gene: 9563 Human Entrez Gene: 100198 Mouse Entrez Gene: 66171 Mouse Entrez Gene: 290636 Rat Entrez Gene: 298655 Rat Omim: 138090 Human Omim: 604951 Human SwissProt: O95336 Human SwissProt: O95479 Human SwissProt: Q8CFX1 Mouse SwissProt: Q9CQ60 Mouse SwissProt: P85971 Rat Unigene: 463511 Human Unigene: 466165 Human Unigene: 22183 Mouse Unigene: 282284 Mouse Unigene: 402679 Mouse Unigene: 17292 Rat Unigene: 19855 Rat

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