Product Name	CBFb
Chinese Name	多瘤病毒增强了Binding protein２β抗体
Alias	CBF b; CBF beta; CBF-beta; CBFbeta; Core binding factor beta subunit; core binding factor subunit beta; Core-binding factor subunit beta; PEA 2; PEA2; PEA2; PEA2 beta; PEA2beta; PEBB_HUMAN; PEBP 2B; PEBP2B; PEBP2 beta; PEBP2-beta; PEBP2B; PEBP2beta; Polyomavirus enhancer binding protein 2 beta subunit; SL3 3 enhancer factor 1 beta subunit; SL3 3 enhancer factor 1 subunit beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core binding factor beta subunit.
literatures	Specific References  (1)     |     SL6984R has been referenced in 1 publications. [IF=1.879] Guangdi Li. et al. The relationship between abnormal Core binding factor-β expression in human cartilage and osteoarthritis. Bmc Musculoskel Dis. 2021 Dec;22(1):1-13  WB ;  Human.   PubMed:33573620
Research Area	Cell biology  immunology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CBFb/PEBP2B: 85-182/182
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1. Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1. Subunit: Heterodimer with RUNX1. Subcellular Location: Nucleus. DISEASE: Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11. Similarity: Belongs to the CBF-beta family. SWISS: Q13951 Gene ID: 865 Database links: Entrez Gene: 865 Human Entrez Gene: 12400 Mouse Entrez Gene: 361391 Rat Omim: 121360 Human SwissProt: Q13951 Human SwissProt: Q08024 Mouse Unigene: 460988 Human Unigene: 2018 Mouse Unigene: 7308 Rat

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