Product Name	BHLHE41
Chinese Name	BHLHE41抗体
Alias	SHARP-1; BHLHB3; DEC2; SHARP1; BHLH3; Basic helix-loop-helix domain containing class B3; bHLH protein DEC2; helix protein 41; Class B basic helix loop helix protein 3; Class B basic helix-loop-helix protein 3; Class E basic helix-loop-helix protein 41; Differentially expressed in chondrocytes protein 2; Enhancer of split and hairy related protein 1; Enhancer-of-split and hairy-related protein 1; hDEC2; Moderately similar to basic-helix loop helix protein M.musculus; BHE41_HUMAN.
literatures	Specific References  (1)     |     SL6932R has been referenced in 1 publications. [IF=3.231] Haiman Xu. et al. Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice. Drug Metab Dispos. 2020 Aug;48(8):681-689  WB ;  Mouse.   PubMed:32527940
Research Area	Tumour  Chromatin and nuclear signals  Neurobiology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SHARP1/DEC2: 21-120/482
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	DEC1 is a 412 amino acid, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes. The bHLH region of DEC1 is structurally similar to the bHLH regions of the mammalian HES family, Drosophila hairy and Drosophila Enhancer of split m7. DEC1 is a novel direct target for cAMP in a wide range of cells, and is involved in the control of gene expression in cAMP-activated cells. DEC2, also known as SHARP1, is highly expressed in skeletal muscle and brain. The gene encoding human DEC2 maps to chromosome 12p11.23-p12.1. DEC1 and DEC2 play a role in regulating the mammalian molecular clock by suppressing the transcription of specific clock genes. Both DEC1 and DEC2 are detected in the suprachiasmimc nucleus in a circadian fashion. Brief light impulses induce the expression of DEC1 in a phase-dependent manner. Function: May be a transcriptional repressor that represses both basal and activated transcription. Subunit: Homodimerize. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain. SWISS: Q9C0J9 Gene ID: 79365 Database links: Entrez Gene: 79365 Human Entrez Gene: 79362 Mouse Entrez Gene: 117095 Rat Omim: 606200 Human SwissProt: Q9C0J9 Human SwissProt: Q99PV5 Mouse SwissProt: O35779 Rat Unigene: 177841 Human Unigene: 154529 Mouse Unigene: 10784 Rat
Product Picture	Sample: Brain (Rat) Lysate at 40 ug Primary: Anti-DEC2 (SL6932R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution Predicted band size: 50 kD Observed band size: 50 kD

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