Product Name	Fibrinogen gamma chain
Chinese Name	纤维蛋白原γ链抗体
Alias	FGG; FIBG_HUMAN; Fibrinogen gamma chain; Fibrinogen gamma polypeptide; fibrinogen gamma-b chain.
literatures	Specific References  (3)     |     SL6895R has been referenced in 3 publications. [IF=16.874] Bingcheng Yi. et al. Step-wise CAG@PLys@PDA-Cu2+ modification on micropatterned nanofibers for programmed endothelial healing. BIOACT MATER. 2022 Jul;:  IHC ;  Human.   PubMed:10.1016/j.bioactmat.2022.07.010 [IF=8.724] Qing Ma. et al. Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents. Bioact Mater. 2021 Dec;6:4786  Other ;   PubMed:34095629 [IF=2.68] Li, Hongyan, et al. "Comparative analysis of the serum proteome for biomarker discovery to reveal hepatotoxicity induced by iron ion radiation in mice." Life Sciences 167 (2016): 57-66.  WB ;  Mouse.   PubMed:27815023
Research Area	Cardiovascular  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	47kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Fibrinogen gamma chain: 151-250/453
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Involvement in disease: Defects in FGG are a cause of thrombophilia. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen. Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain. Subcellular Location: Secreted. Post-translational modifications: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sulfation of C-terminal tyrosines increases affinity for thrombin. DISEASE: Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: P02679 Gene ID: 2266 Database links: Entrez Gene: 2266 Human Entrez Gene: 99571 Mouse Omim: 134850 Human SwissProt: P02679 Human SwissProt: Q8VCM7 Mouse Unigene: 16422 Mouse
Product Picture	Sample: BRL-3A Cell (Rat) Lysate at 40 ug Primary: Anti-Fibrinogen gamma chain (SL6895R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 60 kD Sample: Hcclm3 Cell (Human) Lysate at 40 ug Primary: Anti-Fibrinogen gamma chain (SL6895R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 60 kD Sample: Lane 1: Mouse Kidney tissue lysates Lane 2: Mouse Placenta tissue lysates Lane 3: Human HepG2 cell lysates Primary: Anti-Fibrinogen gamma chain (SL6895R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kDa Observed band size: 47 kDa

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