Product Name	CCBR1
Chinese Name	钙离子通道阻端耐药蛋白CCBR1抗体
Alias	Amino acid transport system xc xCT antibody; Amino acid transport system xc- antibody Calcium channel blocker resistance protein CCBR1; Calcium channel blocker resistance protein CCBR1 antibody; CCBR1; Cysteine/glutamate transporter antibody; cystine/glutamate transporter; SLC7A11; Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7; Solute carrier family 7 member 11; Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; xCT; XCT_HUMAN.
literatures	Specific References  (8)     |     SL6883R has been referenced in 8 publications. [IF=]    PubMed:32937103 [IF=7.31] Huang Bin. et al. Dapagliflozin Ameliorates Renal Tubular Ferroptosis in Diabetes via SLC40A1 Stabilization. OXID MED CELL LONGEV. 2022;2022:9735555  WB, IP ;  Mouse, Human.   PubMed:35993021 [IF=6.244] Li Y. et al. Scutellaria barbata Inhibits Hepatocellular Carcinoma Tumorigenicity by Inducing Ferroptosis of Hepatocellular Carcinoma Cells.. Front Oncol. 2022 Mar;12:693395-693395  WB ;  Mouse,Human.   PubMed:35321425 [IF=4.109] Ruijian Zhuge. et al. Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats. ENVIRON TOXICOL. 2022 Nov;:  IHC ;  Rat.   PubMed:36416502 [IF=3.347] Zixuan Liu. et al. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. Toxicol Appl Pharm. 2020 Nov;407:115241  WB ;  Rat.   PubMed:32937103 [IF=3.231] Yajing Li. et al. Effect of Zearalenone-Induced Ferroptosis on Mice Spermatogenesis. ANIMALS. 2022 Jan;12(21):3026  WB ;  Mouse.   PubMed:36359150 [IF=3.076] Tang Q et al. Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure.Neurotoxicology. 2018 Jul;67:27-36.  WB ;  Mouse.   PubMed:29678591 [IF=0] Lan B et al. Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats. Journal of Integrative Medicine. 2020.  IHC-P ;  Rat.   PubMed:doi:10.1016/j.joim.2020.01.008
Research Area	Cell biology  immunology  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human xCT/CCBR1: 201-300/501 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]. Function: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Subunit: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. SWISS: Q9UPY5 Gene ID: 23657 Database links: UniProtKB/Swiss-Prot: Q9UPY5.1
Product Picture	Sample: Lane 1: Human HepG2 cell lysates Lane 2: Human HeLa cell lysates Primary: Anti-CCBR1 (SL6883R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kDa Observed band size: 57 kDa

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