Product Name	MALT1
Chinese Name	粘膜相关淋巴组织淋巴瘤Transporter1抗体
Alias	Caspase like protein; DKFZp434L132; MALT 1; MALT associated translocation; MALT lymphoma associated translocation; MALT lymphoma-associated translocation; Malt1; MALT1_HUMAN; MLT 1; MLT; MLT1; Mucosa associated lymphoid tissue lymphoma translocation gene 1; Mucosa associated lymphoid tissue lymphoma translocation protein 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Paracaspase.
Research Area	Cell biology  Signal transduction  Apoptosis  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	91kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MALT1: 631-730/824
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Function: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Subunit: Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Subcellular Location: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. Tissue Specificity: Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. DISEASE: Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. Similarity: Belongs to the peptidase C14B family. Contains 1 death domain. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q9UDY8 Gene ID: 10892 Database links: Entrez Gene: 10892 Human Entrez Gene: 240354 Mouse Omim: 604860 Human SwissProt: Q9UDY8 Human SwissProt: Q2TBA3 Mouse Unigene: 601217 Human Unigene: 132613 Mouse

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