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Product Name NLRP10 Chinese Name 富含亮氨酸重复结构域蛋白10抗体 Alias CLR11.1; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD domains containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NAL10_HUMAN; NALP10; NLR family, pyrin domain containing 10; Nlrp10; NOD8; Nucleotide-binding oligomerization domain protein 8; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10; PAN5; PYNOD. Research Area Cell biology Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 75kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NLRP10: 401-500/655 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Tissue specificity: Widely expressed with highest levels in heart, brain and skeletal muscle.
Function:
Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID.
Subcellular Location:
Oligomerizes. Interacts with PYCARD, CASP1 and IL1B.
Tissue Specificity:
Widely expressed with highest levels in heart, brain and skeletal muscle.
Similarity:
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 1 NACHT domain.
SWISS:
Q86W26
Gene ID:
338322
Database links:Entrez Gene: 338322 Human
Entrez Gene: 244202 Mouse
Omim: 609662 Human
SwissProt: Q86W26 Human
SwissProt: Q8CCN1 Mouse
Unigene: 449636 Human
Unigene: 37991 Mouse
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