Product Name	FAIM2
Chinese Name	FAS凋亡抑制分子2抗体
Alias	FAIM 2; Fas apoptotic inhibitory molecule 2; LFG; Lifeguard; Neural membrane protein 35; NGP 35; NGP35; NMP 35; NMP35; Protein lifeguard; TMBIM 2; TMBIM2; Transmembrane BAX inhibitor motif containing 2; Transmembrane BAX inhibitor motif containing protein 2; LFG2_HUMAN.
Research Area	Cell biology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, Monkey, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FAIM2: 211-316/316
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway. Function: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Subunit: Interacts with FAS/TNFRSF6 and BAX. Subcellular Location: Cell membrane; Multi-pass membrane protein (By similarity). Membrane raft. Cell junction, synapse, postsynaptic cell membrane (By similarity). Tissue Specificity: Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. Similarity: Belongs to the BI1 family. LFG subfamily. SWISS: Q9BWQ8 Gene ID: 23017 Database links: Entrez Gene: 23017 Human Entrez Gene: 72393 Mouse Entrez Gene: 246274 Rat Omim: 604306 Human SwissProt: Q9BWQ8 Human SwissProt: Q8K097 Mouse SwissProt: O88407 Rat Unigene: 567424 Human Unigene: 39760 Mouse Unigene: 162026 Rat

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