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Product Name MAGEC1 Chinese Name 黑色素瘤相关抗原C1抗体 Alias Cancer/testis antigen 7.1; Cancer/testis antigen family 7 member 1; CT7; CT7.1; MAGC1_HUMAN; MAGE C1; MAGE C1 antigen; MAGE-C1 antigen; MAGEC1; melanoma antigen family C, 1; Melanoma associated antigen C1; Melanoma-associated antigen C1; MGC39366. Research Area Tumour Cell type markers TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 124kDa Cellular localization The nucleus cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MAGEC1: 1051-1142/1142 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. [provided by RefSeq, Jul 2008]
Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Subunit:
Interacts with TRIM27.
Subcellular Location:
Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient.
Tissue Specificity:
Expressed in testis and in tumors of a wide variety of histologic types.
DISEASE:
Note=May play a role in Prader-Willi syndrome (PWS) which is a contiguous gene syndrome resulting from inactivity of the paternal copies of a number of genes on 15q11, through deletion or disruption of these genes or maternal uniparental disomy 15. The PWS syndrome is characterized by muscular hypotonia, mental retardation, short stature, obesity, hypogonadotropic hypogonadism, and small hands and feet.
Similarity:
Contains 1 MAGE domain.
SWISS:
O60732
Gene ID:
9947
Database links:Entrez Gene: 9947 Human
Omim: 300223 Human
SwissProt: O60732 Human
Unigene: 132194 Human
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