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Product Name MAGEB4 Chinese Name 黑色素瘤相关抗原B4抗体 Alias cancer/testis antigen family 3, member 6; CT3.6; MAGB4_HUMAN; MAGE B4 antigen; MAGE-B4 antigen; MAGEB4 antibody melanoma antigen family B, 4; Melanoma associated antigen B4; Melanoma-associated antigen B4; MGC33144. Research Area Tumour Cell type markers TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 39kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MAGEB4: 51-150/346 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types, but not in normal tissues, with the exception of testis and placenta. Although a large number of MAGE genes have now been identified and extensively studied in tumors of various origin, their function in normal cells remains unknown.
Tissue Specificity:
Expressed in testis.
Similarity:
Contains 1 MAGE domain.
SWISS:
O15481
Gene ID:
4115
Database links:Entrez Gene: 4115 Human
Omim: 300153 Human
SwissProt: O15481 Human
Unigene: 113291 Human
Product Picture Paraformaldehyde-fixed, paraffin embedded (human kidney tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MAGEB4) Polyclonal Antibody, Unconjugated (SL6824R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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