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Product Name CLUAP1 Chinese Name 成簇相关蛋白1抗体 Alias Clusterin associated protein 1; FLJ13297; KIAA0643; CLUA1_HUMAN. Research Area Tumour Cell biology immunology TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 48kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CLUAP1: 35-140/413 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CLUAP1 (Clusterin associated protein 1) is a 413 amino acid nuclear protein that exists as two alternatively spliced isoforms that interact with Clusterin. CLUAP1 is suggested to play a role in apoptosis and cell proliferation, and is expressed in testis, thrachea and thyroid, with low levels found in adrenal gland and spinal cord. The gene encoding CLUAP1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Function:
May play a role in cell proliferation or apoptosis.
Subunit:
Interacts with CLU/clusterin.
Subcellular Location:
Nuclear
Tissue Specificity:
Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland.
SWISS:
Q96AJ1
Gene ID:
23059
Database links:Entrez Gene: 23059 Human
Entrez Gene: 76779 Mouse
SwissProt: Q96AJ1 Human
SwissProt: Q8R3P7 Mouse
Unigene: 155995 Human
Unigene: 458921 Mouse
Unigene: 19522 Rat
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