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Product Name MAP3K10 Chinese Name 丝裂原活化蛋白激酶3K10抗体 Alias Activates the JUN N-terminal pathway; M3K10_HUMAN. Research Area Cell biology Signal transduction Apoptosis Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, ) Applications IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 104kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MLK2/MAP3K10: 421-480/954 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008].
Function:
Activates the JUN N-terminal pathway (By similarity).
Subunit:
Homodimer (By similarity).
Tissue Specificity:
Expressed in brain and skeletal muscle.
Post-translational modifications:
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation (By similarity).
Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 SH3 domain.
SWISS:
Q02779
Gene ID:
4294
Database links:Entrez Gene: 4294 Human
Entrez Gene: 269881 Mouse
Omim: 600137 Human
SwissProt: Q02779 Human
SwissProt: Q66L42 Mouse
Unigene: 466743 Human
Unigene: 389883 Mouse
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