Product Name	M Cadherin
Chinese Name	M钙粘附分子抗体
Alias	M-Cadherin; Cadherin 14; Cadherin 15; Cadherin 3; Cadherin14; Cadherin15; Cadherin3; CCAD; CDH 14; CDH 15; CDH 3; CDH14; CDH15; CDH3; CDHM; MCAD; Muscle cadherin; Myotubule cadherin; CAD15_HUMAN.
Research Area	Cell biology  Neurobiology  Signal transduction  Cell adhesion molecule  Cell Surface Molecule  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	89kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human M-Cadherin: 355-450/814
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cadherins are a family of transmembrane glycoproteins that play a key role in Calcium dependent cell-cell adhesion. Several members of the cadherin family have been identified so far, including E- (epithelial), P- (placental), N- (neuronal) and M- (muscle) cadherin. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. M-Cadherin is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. Subcellular Location: Type 1 membrane protein. Tissue Specificity: Expressed in the brain and cerebellum. DISEASE: Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3) [MIM:612580]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Similarity: Contains 5 cadherin domains. SWISS: P55291 Gene ID: 1013 Database links: Entrez Gene: 1013 Human Entrez Gene: 12555 Mouse Entrez Gene: 361432 Rat Omim: 114019 Human SwissProt: P55291 Human SwissProt: P33146 Mouse Unigene: 148090 Human Unigene: 1976 Mouse
Product Picture	Sample: 293T(Human) Cell Lysate at 30 ug Primary: Anti- M Cadherin (SL6678R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 89 kD Observed band size: 110 kD

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