Product Name	KCNN4
Chinese Name	钙激活钾Channel protein4抗体
Alias	hIKCa1; IK1; IKCa1; Intermediate conductance calcium activated potassium channel protein 4; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCa4; KCNN 4; Kcnn4; KCNN4_HUMAN; Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4; Putative Gardos channel; SK4; SKCa 4; SKCa4.
literatures	Specific References  (3)     |     SL6675R has been referenced in 3 publications. [IF=6.543] Liu Dishiwen. et al. Cardiac Fibroblasts Promote Ferroptosis in Atrial Fibrillation by Secreting Exo-miR-23a-3p Targeting SLC7A11. OXID MED CELL LONGEV. 2022;2022:3961495  WB ;  Dog,Rat.   PubMed:35677105 [IF=4.3] Lively et al. Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels. (2018) Front.Cell.Neurosci. 12:115  WB ;  Rat.   PubMed:29780305 [IF=3.23] Zhang, Panshi, et al. "Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells." PLOS ONE 11.4 (2016): e0154471.  IHC-P ;  Human.   PubMed:27124117
Research Area	Cell biology  Neurobiology  Channel protein  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human KCNN4: 325-427/427
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Subunit: Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in non-excitable tissues. Post-translational modifications: Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel. Similarity: Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. SWISS: O15554 Gene ID: 3783 Database links: Entrez Gene: 3783 Human Entrez Gene: 16534 Mouse Entrez Gene: 65206 Rat Omim: 602754 Human SwissProt: O15554 Human SwissProt: O89109 Mouse SwissProt: Q9QYW1 Rat Unigene: 10082 Human Unigene: 9911 Mouse Unigene: 44212 Rat
Product Picture	Sample: Brain (Rat) Lysate at 40 ug Heart (Rat) Lysate at 40 ug Primary: Anti-KCNN4 (SL6675R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution Predicted band size: 50 kD Observed band size: 48/42 kD

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