Product Name	phospho-HRH1 (Ser398)
Chinese Name	磷酸化组胺受体H1抗体
Alias	HRH1 (phospho S398); p-HRH1 (phospho Ser398); HRH1(phospho S398); H1R; HisH1; Histamine H1 receptor; Histamine receptor H1; Histamine receptor subclass H1.
Product Type	Phosphorylated anti
Research Area	Cell biology  Signal transduction  Growth factors and hormones  transcriptional regulatory factor  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human HRH1 around the phosphorylation site of Ser398: SH(p-S)RQ
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]. Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal transduction through the receptor molecule. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P35367 Gene ID: 3269 Database links: Entrez Gene: 3269 Human Entrez Gene: 15465 Mouse Omim: 600167 Human SwissProt: P35367 Human SwissProt: P70174 Mouse Unigene: 1570 Human Unigene: 333327 Mouse
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-phospho-HRH1(Ser398) (SL6665R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kD Observed band size: 55 kD phosphopeptide non phosphopeptide

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