Product Name	COG1
Chinese Name	COG1蛋白抗体
Alias	Ldlbc; CDG2Gv Component of oligomeric golgi complex 1; Conserved oligomeric Golgi complex protein 1; Low density lipoprotein receptor defect B complementing; COG1_HUMAN.
literatures	Specific References  (1)     |     SL6647R has been referenced in 1 publications. [IF=2.75] Dechtawewat, Thanyaporn, et al. "Mass spectrometric analysis of host cell proteins interacting with dengue virus nonstructural protein 1 in dengue virus-infected HepG2 cells." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics (2016).  IP ;  Human.   PubMed:27108190
Research Area	Cell biology  Signal transduction  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	109kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human COG1: 501-600/980
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	There are eight COG proteins (COG1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that COG1 is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. Function: Required for normal Golgi function (By similarity). Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Subcellular Location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. DISEASE: Defects in COG1 are the cause of congenital disorder of glycosylation type 2G (CDG2G) [MIM:611209]; also known as CDG-II caused by COG1 deficiency. CDGs are a family of severe inherited diseases caused by a defect in glycoprotein biosynthesis. They are characterized by under-glycosylated serum glycoproteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Clinical features of CDG2G include failure to thrive, generalized hypotonia, growth retardation and mild psychomotor retardation. CDG2G is biochemically characterized by a defect in O-glycosylation as well as N-glycosylation. Similarity: Belongs to the COG1 family. SWISS: Q8WTW3 Gene ID: 9382 Database links: Entrez Gene: 9382 Human Entrez Gene: 16834 Mouse Omim: 606973 Human SwissProt: Q8WTW3 Human SwissProt: Q9Z160 Mouse Unigene: 103555 Human Unigene: 261620 Mouse
Product Picture	Sample: Hela Cell (Human) Lysate at 40 ug FHC Cell (Human) Lysate at 40 ug Primary: Anti-COG1 (SL6647R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 109 kD Observed band size: 109 kD Sample: HepG2 Cell (Human) Lysate at 40 ug Primary: Anti-COG1 (SL6647R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 109 kD Observed band size: 109 kD Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (COG1) Polyclonal Antibody, Unconjugated (SL6647R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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