Product Name	WNT7A
Chinese Name	原癌基因wnt7a蛋白抗体
Alias	Protein Wnt-7a; wnt 7a;Protein Wnt-7a precursor; proto-oncogene wnt7a protein; wingless-type MMTV integration site family, member 7A; WNT7A; WNT7A_HUMAN.
literatures	Specific References  (2)     |     SL6645R has been referenced in 2 publications. [IF=5.738] Jianglin Wang. et al. Validation and analysis of expression, prognosis and immune infiltration of WNT gene family in non-small cell lung cancer. FRONT ONCOL. 2022; 12: 911316  WB, IHC ;  Human.   PubMed:35957916 [IF=0.375] ZHANG P et al. 5-Azacytidine and trichostatin A enhance the osteogenic differentiation of bone marrow mesenchymal stem cells isolated from steroid-induced avascular necrosis of the femoral head in rabbit. J Biosci (2019) 44:87.  WB ;  Rabbit.   PubMed:DOI:10.1007/s12038-019-9901-7
Research Area	Tumour  Signal transduction  Stem cells  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human WNT7A: 241-349/349
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts. Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity). Subunit: Interacts with PORCN. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. DISEASE: Defects in WNT7A are the cause of limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820]. A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS) [MIM:228930]; also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. Similarity: Belongs to the Wnt family. SWISS: O00755 Gene ID: 7476 Database links: Entrez Gene: 7476 Human Entrez Gene: 533782 Cow Entrez Gene: 607180 Dog Entrez Gene: 100055450 Horse Entrez Gene: 22421 Mouse Entrez Gene: 100355697 Rabbit Entrez Gene: 114850 Rat Omim: 601570 Human SwissProt: O00755 Human SwissProt: P24383 Mouse Unigene: 72290 Human Unigene: 56964 Mouse
Product Picture	Sample: Brain (Mouse) Lysate at 40 ug Primary: Anti-WNT7A (SL6645R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 50 kD Sample: Lane 1: Mouse Placenta tissue lysates Lane 2: Mouse Lung tissue lysates Lane 3: Mouse Testis tissue lysates Lane 4: Mouse Kidney tissue lysates Lane 5: Rat Placenta tissue lysates Lane 6: Rat Lung tissue lysates Lane 7: Rat Testis tissue lysates Lane 8: Rat Kidney tissue lysates Lane 9: Human Hela cell lysates Lane 10: Human A431 cell lysates Lane 11: Human SH-SY5Y cell lysates Lane 12: Human HepG2 cell lysates Primary: Anti- WNT7A (SL6645R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kDa Observed band size: 41 kDa Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (WNT7A) Polyclonal Antibody, Unconjugated (SL6645R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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