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Product Name ZDHHC17 Chinese Name NFκB激活蛋白205抗体 Alias HSPC294; Putative MAPK activating protein PM11; Putative NF kappa B activating protein 205; Zinc finger DHHC domain containing protein 17; DHHC domain containing 17; HIP14; HIP3; huntingtin interacting protein 14; huntingtin interacting protein 3; Huntingtin interacting protein H; HYPH; KIAA0946; ZDHHC 17; zinc finger; ZDH17_HUMAN. Research Area Neurobiology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 73kDa Cellular localization cytoplasmic The cell membrane Extracellular matrix Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ZDHHC17: 365-460/632 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail ZDHHC17 is a neuronal palmitoyl transferase. Palmitoylation is critical for trafficking and function of signaling molecules, neurotransmitter receptors, and synaptic scaffolding proteins in neurons. ZDHHC17 causes cellular transformation. It has been shown that mRNA encoding ZDHHC17 is up-regulated in a number of types of human tumors, thus ZDHHC17 and other PATs (palmitoyl acyltransferases) are potential targets for new anticancer drugs.
Function:
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport.
Subunit:
Interacts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.
Subcellular Location:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.
Tissue Specificity:
Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes.
Post-translational modifications:
Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport.
Similarity:
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
Contains 5 ANK repeats.
Contains 1 DHHC-type zinc finger.
SWISS:
Q8IUH5
Gene ID:
23390
Database links:Entrez Gene: 23390 Human
Entrez Gene: 320150 Mouse
Omim: 607799 Human
SwissProt: Q8IUH5 Human
SwissProt: Q80TN5 Mouse
Unigene: 4014 Human
Unigene: 339281 Mouse
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