Product Name	CRHR2
Chinese Name	促肾上腺皮质释放激素受体2抗体
Alias	Corticotropin releasing hormone receptor 2; Corticotropin-releasing factor receptor 2; Corticotropin-releasing hormone receptor 2; CRF 2; CRF 2R; CRF R2; CRF-R-2; CRF-R2; CRF2; CRF2R; CRFR 2; CRFR-2; CRFR2; CRFR2_HUMAN; CRH 2R; CRH R2; CRH-R-2; CRH-R2; CRH2R; CRHR 2; CRHR2.
Research Area	Cell biology  Neurobiology  G protein-coupled receptor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Pig, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CRHR2: 85-190/411 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Subunit: Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 2 family. SWISS: Q13324 Gene ID: 1395 Database links: Entrez Gene: 1395 Human Entrez Gene: 12922 Mouse Entrez Gene: 64680 Rat Omim: 602034 Human SwissProt: Q13324 Human SwissProt: Q60748 Mouse SwissProt: P47866 Rat Unigene: 546246 Human Unigene: 236081 Mouse Unigene: 10023 Rat
Product Picture	Sample: Lane 1: Heart (Mouse) Lysate at 40 ug Lane 2: Cerebrum (Mouse) Lysate at 40 ug Lane 3: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-CRHR2 (SL6620R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 48-52 kD Observed band size: 48 kD

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