Product Name	HSD17B1
Chinese Name	羟类固醇脱氢酶17β抗体
Alias	17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; DHB1_HUMAN; E2DH; EDH17B2; EDHB17; Estradiol 17 beta dehydrogenase 1; Estradiol 17-beta-dehydrogenase 1; HSD17; HSD17B1; Hydroxysteroid (17 beta) dehydrogenase 1; Placental 17 beta hydroxysteroid dehydrogenase; Placental 17-beta-hydroxysteroid dehydrogenase.
literatures	Specific References  (1)     |     SL6603R has been referenced in 1 publications. [IF=8.469] Xiaofeng Zhou. et al. DNA methylation mediated RSPO2 to promote follicular development in mammals. Cell Death Dis. 2021 Jun;12(7):1-13  WB ;  Pig.   PubMed:34175894
Research Area	Tumour  Neurobiology  Signal transduction  Growth factors and hormones  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HSD17B1: 21-120/328
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Function: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. Subunit: Homodimer. Subcellular Location: Cytoplasm. Similarity: Belongs to the short-chain dehydrogenases/reductases SWISS: P14061 Gene ID: 3292 Database links: Entrez Gene: 3292 Human Omim: 109684 Human SwissProt: P14061 Human Unigene: 654385 Human Unigene: 655222 Human
Product Picture	Sample: Ovary (Mouse) Lysate at 40 ug Primary: Anti-HSD17B1 (SL6603R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kD Observed band size: 36 kD Sample: Placenta (Mouse) Lysate at 40 ug Primary: Anti-HSD17B1 (SL6603R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kD Observed band size: 38 kD

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