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Product Name Desmoglein 3 Chinese Name 桥粒芯蛋白3抗体 Alias 130 kD pemphigus vulgaris antigen; Balding; CDHF 6; CDHF6; Desmoglein 3 precursor; Desmoglein3; DKFZp686P23184; DSG 3; DSG3; DSG-3; Pemphigus vulgaris antigen; PVA; DSG3_HUMAN. literatures Specific References (3) | SL6585R has been referenced in 3 publications.[IF=4.996] Oike, Asami. et al. Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells. SCI REP-UK. 2022 Dec;12(1):1-15 IF ; Mouse.[IF=4.3] Sumitomo et al. Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection. (2018) Front.Cell.Infect.Microbiol. 8:10 IF(IHC-P) ; Mouse.[IF=0.32] BİR, Ferda, et al. "New immunohistochemical markers in the differential diagnosis of nonsmall cell lung carcinoma." Turkish Journal of Medical Sciences (2016). IHC-P ; Human.Research Area Signal transduction Cell adhesion molecule Cytoskeleton Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Dog, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 105kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Desmoglein 3: 50-75/999 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Tissue Specificity:
Epidermis, tongue, tonsil, esophagus and carcinomas.
Similarity:
Contains 4 cadherin domains.
SWISS:
P32926
Gene ID:
1830
Database links:Entrez Gene: 1830 Human
Omim: 169615 Human
SwissProt: P32926 Human
Unigene: 1925 Human
Product Picture Tissue/cell: rat tongue tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Desmoglein 3 Polyclonal Antibody, Unconjugated(SL6585R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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