Product Name	LRRN5
Chinese Name	富含亮氨酸重复神经元5抗体
Alias	Fibronectin type III immunoglobulin and leucine rich repeat domain 7; FIGLER7; GAC 1; GAC1; Glioma amplified on chromosome 1; Glioma amplified on chromosome 1 protein; Leucine rich and ankyrin repeats 1; Leucine rich repeat neuronal 2; Leucine rich repeat neuronal 5; Leucine rich repeat neuronal protein 2; Leucine rich repeat neuronal protein 5; LRANK 1; LRANK1; LRRN 2; LRRN 5; LRRN2; LRRN2_HUMAN.
Research Area	Tumour  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	77kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LRRN5: 601-713/713 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Overamplified in malignant gliomas. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 12 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: O75325 Gene ID: 10446 Database links: Entrez Gene: 10446 Human Omim: 605492 Human SwissProt: O75325 Human Unigene: 26312 Human

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