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Rabbit Anti-LDOC1 antibody
Rabbit Anti-LDOC1 antibody
BCUR1; Breast cancer up regulated 1; Breast cancer upregulated 1; Gm366; Leucine zipper down regulated in cancer 1; Leucine zipper protein down regulated in cancer cells; Leucine zipper protein down regulated in cancer cells; Mar7; Mart7; Protein LDOC1; R
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Details

Product Name LDOC1
Chinese Name 癌症亮氨酸拉链下调因子1抗体
Alias BCUR1; Breast cancer up regulated 1; Breast cancer upregulated 1; Gm366; Leucine zipper down regulated in cancer 1; Leucine zipper protein down regulated in cancer cells; Leucine zipper protein down regulated in cancer cells; Mar7; Mart7; Protein LDOC1; RGD1565644; LDOC1_HUMAN .  
Research Area Tumour  Chromatin and nuclear signals  Signal transduction  transcriptional regulatory factor  TumourCell biologyMaker  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Dog, Pig, Horse, Rabbit, )
Applications ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 17kDa
Cellular localization The nucleus 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human LDOC1: 65-146/146 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008].

Function:
May have an important role in the development and/or progression of some cancers.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitously expressed with high levels in brain and thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.

Similarity:
Belongs to the LDOC1 family.

SWISS:
O95751

Gene ID:
23641

Database links:

Entrez Gene: 23641 Human

Omim: 300402 Human

SwissProt: O95751 Human

Unigene: 45231 Human



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