Product Name	SKALP
Chinese Name	弹性蛋白酶抑制剂抗体
Alias	ELAF_HUMAN; Elafin; Elastase Specific Inhibitor; Elastase-specific inhibitor; ES 1; ESI; Peptidase inhibitor 3; PI 3; PI-3; PI3; Protease inhibitor 3 skin derived; Protease inhibitor WAP3; SKALP; Skin derived Anti leukoproteinase; Skin-derived antileukoproteinase; Trappin 2; WAP four disulfide core domain protein 14; WAP four-disulfide core domain protein 14; WFDC14.
Research Area	Tumour  Cell biology  immunology  Signal transduction  Bacteria and viruses  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	13kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SKALP/Elafin: 61-117/117
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008] Function: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Subcellular Location: Secreted. Similarity: Contains 1 WAP domain. SWISS: P19957 Gene ID: 5266 Database links: Entrez Gene: 5266 Human Omim: 182257 Human SwissProt: P19957 Human Unigene: 112341 Human Elafin,又称SKALP(Skin-derived antileucoproteinase)或弹性蛋白酶特异性抑制剂(Elastase-Specific Inhibitor,ESI),它是一种低分子量的弹性蛋白酶抑制剂。它属于“trappin”蛋白家族Trappin-2,具有拮抗胰弹性蛋白酶、中性粒细胞弹性蛋白酶(NE)和蛋白酶3的作用。

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