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Product Name CD39L4 Chinese Name 原癌基因CD39样蛋白4/ENTPD5抗体 Alias CD39 like 4; AI196558; AI987697; CD39 antigen like 4; CD39 antigen-like 4; CD39 like 4; CD39L4; Ectonucleoside triphosphate diphosphohydrolase 5; ENTP5_HUMAN; Entpd5; ER UDPase; ER-UDPase; GDPase ENTPD5; Guanosine-diphosphatase ENTPD5; MGC163357; MGC163359; mNTPase; NTPDase 5; Nucleoside diphosphatase; PCPH; Pcph proto oncogene protein; Proto oncogene CPH; UDPase ENTPD5; Uridine-diphosphatase ENTPD5 literatures Specific References (1) | SL6526R has been referenced in 1 publications.[IF=3.725] Moyuru Hayashi. et al. Water intake accelerates ATP release from myofibroblast cells in rats: ATP-mediated podoplanin-dependent control for physiological function and immunity. Am J Physiol-Gastr L. 2021 Jan;320(1):G54-G65Research Area Tumour Chromatin and nuclear signals Signal transduction TumourCell biologyMaker The new supersedes the old Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 47kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ENTPD5/CD39L4: 331-380/428 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.
Function:
Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling
Subcellular Location:
Endoplasmic reticulum membrane, Single-pass type II membrane protein
Tissue Specificity:
Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.
Post-translational modifications:
N-glycosylated; high-mannose type
Similarity:
Belongs to the GDA1/CD39 NTPase family.
SWISS:
O75356
Gene ID:
957
Database links:Entrez Gene: 957 Human
Entrez Gene: 12499 Mouse
Omim: 603162 Human
SwissProt: O75356 Human
SwissProt: Q9WUZ9 Mouse
Unigene: 720540 Human
Unigene: 10211 Mouse
Unigene: 63533 Rat
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