Product Name	CDK5RAP3
Chinese Name	周期素依赖性激酶5激活Binding proteinC53抗体
Alias	C53; CDK5 activator binding protein C53; CDK5 regulatory subunit associated protein 3; HSF 27; HSF27; IC53; Ischemic heart CDK5 activator binding protein C53; LXXLL/leucine zipper containing ARFbinding protein; LZAP; MST016; OK/SW cl.114; PP1553; CK5P3_HUMAN.
Research Area	Tumour  Cell biology  Signal transduction  Cyclin  transcriptional regulatory factor  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	57kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CDK5RAP3: 51-150/506
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation. Function: CDK5RAP3 may be involved in cell proliferation through regulation of the CDK5 family by interaction with CDK5 receptor 1. Subunit: Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3. Interacts with the enteric adenovirus serotype 41 fiber protein. Interacts with UFL1. Tissue Specificity: Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta. Post-translational modifications: Phosphorylated in vitro by CDK5 Similarity: Belongs to the CDK5RAP3 family. SWISS: Q96JB5 Gene ID: 80279 Database links: Entrez Gene: 80279 Human Entrez Gene: 80280 Mouse Entrez Gene: 80278 Rat Omim: 608202 Human SwissProt: Q96JB5 Human SwissProt: Q99LM2 Mouse SwissProt: Q9JLH7 Rat Unigene: 20157 Human Unigene: 28297 Mouse Unigene: 3727 Rat

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