Product Name	MTCBP1
Chinese Name	膜型基质金属蛋白酶胞质尾Binding protein1抗体
Alias	ADI 1; Adi1; Adi-1; ADI1 antibody; APL1; ARD; EC 1.13.; Membrane type 1 matrix metalloproteinase cytoplasmic tail binding protein 1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MTCBP 1; MTCBP-1; MTCBP1; MTND_HUMAN; Ni-ARD; SIPL; Submergence induced protein 2 homolog; Submergence-induced protein 2 homolog; 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Aci reductone dioxygenase; Acireductone dioxygenase (Ni(2+)-requiring); Acireductone dioxygenase 1
Research Area	Tumour  Signal transduction  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MTCBP1: 81-126/179
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	his gene encodes an enzyme that belongs to theaci-reductone dioxygenase family of metal-binding enzymes, whichare involved in methionine salvage. This enzyme may regulate mRNAprocessing in the nucleus, and may carry out different functionsdepending on its localization. Related pseudogenes have beendefined on chromosomes 8 and 20. Function: Catalyzes the formation of formate and2-keto-4-methylthiobutyrate (KMTB) from1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Alsodown-regulates cell migration mediated by MMP14. Necessary forhepatitis C virus replication in an otherwise non-permissive cellline. Subunit: Monomer (By similarity). Interacts with MMP14. Subcellular Location: Cytoplasm. Nucleus. Cell membrane;Peripheral membrane protein; Cytoplasmic side. Note=Localizes tothe plasma membrane when complexed to MMP14. Tissue Specificity: Detected in heart, colon, lung, stomach,brain, spleen, liver, skeletal muscle and kidney. Similarity: Belongs to the acireductone dioxygenase (ARD) family. SWISS: Q9BV57 Gene ID: 55256 Database links: Entrez Gene: 55256 Human Entrez Gene: 104923 Mouse Entrez Gene: 298934 Rat NCBI: NP_060739.2 Human Omim: 613400 Human SwissProt: Q9BV57 Human SwissProt: Q99JT9 Mouse SwissProt: Q562C9 Rat Unigene: 502773 Human Unigene: 291504 Mouse Unigene: 12694 Rat

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