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Product Name Carboxypeptidase H Chinese Name 胰羧肽酶E抗体 Alias Carboxypeptidase E; Carboxypeptidase-E; Carboxypeptidase H; Carboxypeptidase H precursor; CarboxypeptidaseE; CarboxypeptidaseH; CBPE_HUMAN; CPE; Cph 1; CPH; Cph1; Enkephalin convertase; Entephalin convertase; Prohormone processing carboxypeptidase; Prohormone-processing carboxypeptidase. Research Area Tumour Cell biology immunology Neurobiology Growth factors and hormones Diabetes Endocrinopathy Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 48kDa Cellular localization The nucleus cytoplasmic The cell membrane Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Carboxypeptidase E: 201-300/476 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Subcellular Location:
Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.
soform 2: Nucleus.
Tissue Specificity:
Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
Similarity:
Belongs to the peptidase M14 family.
SWISS:
P16870
Gene ID:
1363
Database links:Entrez Gene: 1363 Human
Entrez Gene: 12876 Mouse
Omim: 114855 Human
SwissProt: P16870 Human
SwissProt: Q00493 Mouse
Unigene: 75360 Human
Unigene: 31395 Mouse
Unigene: 470333 Mouse
Unigene: 7149 Rat
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