Product Name	kir 6.1
Chinese Name	ATP敏感钾离子Channel protein抗体
Alias	Kir6.1; inwardly rectifying subfamily J member 8; ATP sensitive inward rectifier potassium channel 8; ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; Inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel Kir6.1; IRK 8; IRK8; IRK8_HUMAN; KCNJ8; Potassium channel; Potassium channel, inwardly rectifying subfamily J member 8; potassium inwardly rectifying channel J8; uKATP 1; uKATP-1.
literatures	Specific References  (2)     |     SL6468R has been referenced in 2 publications. [IF=2.74] Hessah Al-Shammari. et al. Expression and function of mechanosensitive ion channels in human valve interstitial cells. Plos One. 2020 Oct;15(10):e0240532  WB ;  Human.   PubMed:33057457 [IF=0.91] Horii K et al. ATP-dependent potassium channels contribute to motor regulation of esophageal striated muscle in rats. J Vet Med Sci. 2019 Jul 9.  IHC-P ;  Rat.   PubMed:31292350
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Neurobiology  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human kir 6.1: 61-160/424 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Predominantly detected in fetal and adult heart. DISEASE: Note=Defects in KCNJ8 may be associated with susceptibility to J-wave syndromes, a group of heart disorders characterized by early repolarization events as indicated by abnormal J-wave manifestation on electrocardiogram (ECG). The J point denotes the junction of the QRS complex and the ST segment on the ECG, marking the end of depolarization and the beginning of repolarization. An abnormal J wave is a deflection with a dome or hump morphology immediately following the QRS complex of the surface ECG. Examples of J-wave disorders are arrhythmias associated with an early repolarization pattern in the inferior or mid to lateral precordial leads, Brugada syndrome, some cases of idiopathic ventricular fibrillation (VF) with an early repolarization pattern in the inferior, inferolateral or global leads, as well as arrhythmias associated with hypothermia. Defects in KCNJ8 may be a cause of susceptibility to sudden infant death syndrome (SIDS) [MIM:272120]. SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily. SWISS: Q15842 Gene ID: 3764 Database links:
Product Picture	Sample: Heart(Rat) Lysate at 40 ug Primary: Anti- kir 6.1 (SL6468R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 48 kD Observed band size: 48 kD

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