Product Name	PEN2
Chinese Name	早老素γ分泌酶2抗体
Alias	Gamma secretase subunit PEN 2; Gamma Secretase Subunit PEN2; Gamma-secretase subunit PEN-2; Hematopoietic stem/progenitor cells protein MDS033; MDS033; MSTP064; PEN 2; PEN-2; PEN2_HUMAN; Presenilin Enhancer 2; Presenilin enhancer 2 homolog; Presenilin Enhancer Protein 2; PSEN2; PSENEN.
literatures	Specific References  (1)     |     SL6456R has been referenced in 1 publications. [IF=2.2] Chu et al. Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice. (2015) Acta.Biochim.Biophys.Sin.(Shanghai). 47:258-66  IF ;  Mouse.   PubMed:25736404
Research Area	Cell biology  immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	11kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PEN2 : 6-80/101
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Subunit: Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Subcellular Location: Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi. Tissue Specificity: Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Similarity: Belongs to the PEN-2 family. SWISS: Q9NZ42 Gene ID: 55851 Database links: Entrez Gene: 55851 Human Entrez Gene: 66340 Mouse Entrez Gene: 292788 Rat Entrez Gene: 81751 Rat Omim: 607632 Human SwissProt: Q9NZ42 Human SwissProt: Q9CQR7 Mouse SwissProt: O88777 Rat SwissProt: Q6QI68 Rat Unigene: 534465 Human Unigene: 86557 Mouse Unigene: 1240 Rat

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